The long reads and the low sequence context bias of PacBio SMRT sequencing allow you to characterize targeted regions of interest irrespective of their genetic complexity ranging in size from several hundred base pairs to 15 kb. With SMRT sequencing you can detect all variant types including structural variants, rare SNPs, indels, copy number variation, microsatellites, haplotypes, and phased alleles. Compare to short-read sequencing, sequence through low complexity regions like repeat expansions, promoters, and flanking regions of transposable elements is possible.

TGIA can work with you to plan, design, and amplify/capture the target genes to get long insert libraries.